Almac Discovery, a research driven drug discovery company and member of the Almac Group, has announced the nomination of a new pre-clinical candidate molecule (ALM-401), a First in Class Bispecific Antibody Drug Conjugate (ADC) for the treatment of refractory lung cancer, characterised by dual expression of ROR1 and EGFR.
This molecule has arisen from the collaboration with Elasmogen Ltd.
ALM-401 has demonstrated an excellent preclinical efficacy profile in a range of models when benchmarked against clinical stage ROR1 targeting ADCs, as well as strong preclinical development potential.The bispecific nature of ALM-401 enhances both the activity and selectivity of the product relative to monospecific drug conjugates, delivering sustained regressions in a series of NSCLC PDX models, and with a consistently improved efficacy profile relative to a clinical stage monospecific ROR1 targeting ADC. ALM-401 has a pleiotropic mechanism of action: in addition to direct tumour cell-killing, it blocks EGFR-mediated signalling and induces bystander killing for increased therapeutic activity. The architecture of ALM-401 has been designed to be half the size of a conventional ADC to promote improved tumour penetration and ease of manufacture.
GO TO First in Class Bispecific Almac/Elasmogen to see the PRESS RELEASE