ELN28 Publications
A Rationally Designed Novel Bifunctional Human TNF-α- and Janus Kinase-Targeted soloMER Drug Conjugate (SDC) with a Neutrophil Elastase Cleavable Linker Delivering Inflammation Site-Specific Release of Payload
Euan Murray, Stella Priyanka, Julia Martinez-Fraile, Ruslan Grygorash, Mohannad Idress, Luke C. Brownbridge, Stella Glavina, Nicolas Camper, Robert Boyd, Andrew J. Porter, Caroline J. Barelle and Obinna C. Ubah
The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors.
Ubah OC, Lake EW, Ott KL, Priyanka S, Celeda S, West JL, Gunaratne GS, Shi K, Moeller NH, Porter AJ, Aihara H, Kosoff D, LeBeau AM, Barelle CJ.Nat Commun. 2025 Nov 29. doi: 10.1038/s41467-025-66967-3
An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model.
Ubah Obinna C., Steven John, Porter Andrew J., Barelle Caroline J.
Frontiers in Immunology 2019 March 10:526. doi: 10.3389/fimmu.2019.00526
Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development.
Ubah OC, Steven J, Kovaleva M, Ferguson L, Barelle C, Porter AJR, Barelle CJ.
Front Immunol. 2017 Oct 23;8:1780. doi: 10.3389/fimmu.2017.01780. eCollection 2017.
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